*Wrote and approved protocol documents for technology transfers between PRP and Brookwood Pharmaceuticals, and provided scientific and engineering expertise during execution of transfers
*Responsible for continuing process development of internal PRP projects

*Worked on various development projects related to API production, encapsulation of API in degradable PLGA microspheres for internal projects and external client programs, delivery of microparticles through small-gauge needles, and process scale-up and scale-down
*Completed initial process development activities on three external client projects, delivering degradable microparticle formulations to clients on schedule
*Supported the formulation development group through the transition from late-stage formulation development into initial scale-up and process development
∑ In process development studies with pegylated Insulin, the API in InsuLAR microshperes, was able to increase the design space for the API production process and optimize reaction and prep LC steps, resulting in a cost savings of more than 33 percent per gram of pegylated Insulin
*Supported manufacturing personnel during production of early large scale batches of pegylated Insulin
*Wrote batch records and raw material acceptance criteria, and contributed to other documentation for production and acceptance of GLP/GMP materials

*Incorporated bio-active hyaluronic acid and fibrinogen to PEG hydrogels in order to increase the production, retention and aggregation of matrix molecules secreted by encapsulated chondrocytes

*Investigated photocrosslinked hydrogel systems for tissue-engineered cartilage applications
*Improved our understanding of the effects of hydrogel degradation profiles on the distribution and biochemical composition of cell-secreted matrix components, and on the evolution of the tissue-biomaterial and tissue-neotissue interface
*Synthesized hydrogel materials with an externally controllable, enzymatic degradation pathway
*Investigated non-destructive ultrasound monitoring of matrix development through a collaboration with researchers at NIST materials reliability division, Boulder, CO
*Contributed significantly to a successful NIH proposal entitled, ìOnline Monitoring and Control of Functional Cartilage Regeneration in Hydrogelsî
*Supervised five undergraduate students in the lab, for periods ranging from 10 weeks to 1.5 years

Chemical Engineering

Chemical Engineering