• Job Target: scientist
• Employment Status: Unspecified
• Experience Level: Not Specified
• Seeking: Full-Time
• Industry: Pharmaceutical Resumes

• Salary:
• Degree: Not Specified
• Security Clearance: None
• Travel: Not Specified
• Relocate:: No

Objective

GENERAL QUALIFICATION ? Experienced in DNA recombination and site-directed mutagenesis, protein expression, purification (liquid chromatography), and labeling ? Expert in biochemical and biophysical assays of proteins including spectroscopic methods (EPR, fluorescence) and x-ray crystallography ? Proficient in structural and functional studies in protein especially membrane protein EDUCATION Nanjing University B.S. JULY, 1990 Physiology Nanjing, China Peking University M.S. JUNE, 1999 Neurophysiology Beijing, China Vanderbilt University Ph.D. AUG, 2005 Biophysics Nashville, TN, USA RESEARCH EXPERIENCE ? 2005 ñpresent, Postdoctoral Fellow, M D Anderson Cancer center a. biochemical and structural studies on multidrug resistance regulatory proteins, EbrR: having collected diffraction data of apo and drug bound forms of protein crystals, having solved three EbrR structures so far. b. biochemical and structural studies of multidrug transporters QacC: having obtained protein crystals, both apo and drug bound, doing optimization of crystallization condition. ? 2001-2005, graduate research, Vanderbilt University, School of Medicine. a. structural and functional analysis of multidrug transporter MsbA with site-directed spin labeling and electron paramagnetic resonance spectroscopy: found conformational changes associated protein function, results published in Science magzine. b. dynamics of quaternary structure of small heat shock protein Hsp27 ? 1996- 1999, Graduate research, Peking University, College of Life Sciences. a. Regulation of hibernation by noradrenline in hypothalamus in ground squirrels (Citelleus dauricus) PUBLICATIONS 1. Dong J, Yang G, Mchaourab HS (2005). Structural Basis of Energy Transduction in the Transport Cycle of MsbA. Science, 308:1023-1028. 2. Shashidharamurthy R, Koteiche HA, Dong J, Mchaourab HS (2005). Mechanism of Chaperone Function in Small Heat-Shock Proteins. Dissociation of the Hsp27 Oligomer is Required for Recognition and Binding of Destabilized T4 Lysozyme. The Journal of Biological Chemistry, 280:5281-5289. 3. Sun J, Ma Y, Xu z, Zhao W, Dong J, Cai Y (1998) Changes of Characteristics of Preoptic Neurons and NA Metabolism in Hypothalamus of Ground Spquirrels (Citelleus dauricus) in Different Seasons and Hibernating Phases. Science in China, 41(5): 488-497. 4. Dong J (1996) The Spontaneous Firing Pattern of Striatal Spiny Neurons (Chinese). The Journal of Xuzhou Teachers College, 14(1): 1-3. 5. Dong J (1993) Effects of Gigantocellularis Recticularis Neucleus Stimulation on Spontaneous Activities of Purkinje Cells in the Cerebellar Cortex of Rats (Chinese). The Journal of Xuzhou Teachers College, 11(2): 33-40. INTERNATIONAL CONFERENCES 1. Functional Dynamics of the ABC Transporter MsbA (Talk and Poster). Jinhui Dong, Hassane S. Mchaourab. 18th SYMPOSIUM OF THE PROTEIN SOCIETY: YOUNG PROTEIN SCIENTISTS SYMPOSIUM, August 14-18, 2004. 2. Functional Dynamics of the ABC Transporter MsbA (Talk). Jinhui Dong, Hassane S. Mchaourab. 46th ROCKY MOUNTAIN CONFERENCE ON ANALYTICAL CHEMISTRY, August 1-5, 2004. 3. Sequence Determinants of Quaternary Structure Flexibility in Hsp27 (Poster). Jinhui Dong, Hanane A. Koteiche, and Hassane S. Mchaourab. ARVO (THE ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY) 2002 ANNUAL MEETING, April 29-May 4, 2002.

Job Target

scientist